11/20/2023 0 Comments Alopecia universalis treatment 2015![]() A remaining total of 44 articles were then included in our review, and references of included articles were further screened for pertinent literature. commentary, protocol, conference report, guidelines, review), and 25 for being written in a non-English language. Upon screening, 228 articles were excluded for failing to mention alopecia areata and complementary/alternative medicine in the article, 78 for publication type (e.g. The contents of each article were manually reviewed, and the article was subsequently included if it was published in English, conducted on human subjects with AA, and featured complementary or alternative therapies as the primary intervention. Upon restricting the search results to full text and performing deduplication, our search yielded 375 articles. MethodsĪ literature search was conducted in the Pub-Med, EMBASE, and Cochrane Central Register of Controlled Trials databases using the following Medical Subject Heading (MeSH) terms: (alopecia) and (complementary, alternative, integrative, traditional, homeopathic, natural, acupuncture, acupressure, massage, vitamin, cryotherapy, aromatherapy, hypnosis, biofeedback, phytotherapy, herb, herbal, or oil). Though the quality of evidence for some CAM therapies remains fairly limited, this narrative review aims to summarize the proposed mechanism, efficacy, and adverse events of recent complementary and alternative therapies for AA. Given the variable efficacy of existing therapies and their associated side effects, some patients may also turn to complementary and alternative medicine (CAM). 3 Moreover, reported efficacy of these treatments remain modest according to a network meta-analysis, which outlined response rates of topical corticosteroids (67.9% 50.1%), diphenylcyclopropenone (63.4% 87.9%), and topical minoxidil (61.2% 55.5%) for mild and moderate-to-severe AA. 3 Other conventional therapies include topical corticosteroids, diphenylcyclopropenone, or topical minoxidil, which may be associated with atrophy, pruritus, and dermatitis. 3 Baricitinib is an oral janus kinase (JAK) inhibitor that, while showing impressive efficacy, is currently only approved for adults with severe AA and has a number of potentially concerning side effects including infections, increased risk of death, increased cancer risk, blood clots, and increased risk of major adverse cardiovascular events. Until the approval of oral baricitinib in 2022, there was no consensus guideline or FDA-approved conventional medication for treating AA. ![]() 1,2 Therefore, treatment for AA focuses on halting disease progression and stimulating hair growth. This condition can significantly impact an individual’s quality of life, often affecting emotional and mental health. In severe cases, AA can cause complete hair loss of the scalp (alopecia totalis) or entire body (alopecia universalis). Alopecia areata (AA) is a chronic autoimmune disease of hair follicles, resulting in patches of nonscarring hair loss.
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